|
KMID : 0381120210430121381
|
|
Genes and Genomics
2021 Volume.43 No. 12 p.1381 ~ p.1388
|
|
|
Rare minisatellite alleles of MUC2-MS8 influence susceptibility to rectal carcinoma
|
|
Seol So-Young
Yang Gi-Eun
Cho Yoon
Kim Min-Chan
Choi Hong-Jo
Choi Yung-Hyun
Leem Sun-Hee
|
|
|
Abstract
|
|
|
Background: Previously, we identified eight novel minisatellites in the MUC2, of which allelic variants in MUC2-MS6 were examined to influence susceptibility to gastric cancer. However, studies on the susceptibility to gastrointestinal cancer of other minisatellites in the MUC2 region still remain unprogressive.
Objective: In this study, we investigated whether polymorphic variations in the MUC2-MS8 region are related to susceptibility to gastrointestinal cancer.
Methods: We assessed the association between MUC2-MS8 and gastrointestinal cancers by a case?control study with 1229 controls, 486 gastric cancer cases, 220 colon cancer cases and 278 rectal cancer cases. To investigate whether intronic minisatellites affect gene expression, various minisatellites were inserted into the luciferase-reporter vector and their expression levels were examined. We also examined the length of MUC2-MS8 alleles in blood and cancer tissue matching samples of 107 gastric cancer patients, 125 colon cancer patients, and 85 rectal cancer patients, and investigated whether the repeat sequence affects genome instability.
Results: A statistically significant association was identified between rare MUC2-MS8 alleles and the occurrence of rectal cancer: odds ratio (OR), 6.66; 95% confidence interval (CI), 1.11?39.96; and P?=?0.0165. In the younger group (age,?
Conclusion: Our results suggest that the rare alleles of MUC2-MS8 could be used to identify the risk of rectal cancer and that this repeat region is related to genomic instability.
|
|
|
KEYWORD
|
|
|
MUC2, Rectal cancer risk, VNTR, LOH
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|